Frequently Asked Questions

Hyaluronic Acid (HA) is a molecule found naturally throughout the human body especially the joint fluid called synovial fluid. However, the HA in your synovial fluid is continuously broken down and replaced over time. During a progression of OA, the HA is broken down faster than it should be regenerating in the synovial fluid.

HA is an important component of the synovial fluid. The synovial fluid enables joints to move easily and freely while providing shock absorption in the joint during physical activity. In a healthy joint, the synovial fluid helps to protect bones and other joint tissues from injury and disease. The synovial fluid also supplies oxygen and nutrients and removes carbon dioxide and metabolic wastes from the cartilage cells in the surrounding cartilage.

Hyruan ONE is a cross-linked, single injection and formulated as high molecular weight (10 Million Dalton*) indicated for the treatment of osteoarthritis (OA) of knee, shoulder, ankle and hip.

With this unique combination, Hyruan ONE offers double mode of action with just ONE injection. First, it provides mechanical protection to the joint, shock absorbing effect and lubrication. Secondly, it provides biological effects such as anti-inflammatory, pain relief and protection to the cartilage surface up to six months** as well as replacing diseased synovial fluid and to restore the visco-elasticity loss in the knee joint caused by osteoarthritis (OA)

*Molecular weight of synovial fluid of young and healthy adults is between 6-10 Million Dalton.
**Pain relief duration may vary across patient to patient depending on the severity of knee OA stages. ?

A steroid injection is generally a powerful anti-inflammatory drug to reduce inflammation and provide immediate pain relief. Steroid injection is usually considered if the joint is having acute pain and inflammation. It usually works faster than a hyaluronic acid injection, however, the pain relief doesn’t last as long and has it’s disadvantages such as making your cartilage wear off faster and making your bone porous.

Studies have shown that steroid injections provide pain relief up to a few weeks and could not be repeated for more than 3 times a year. However, Hyruan ONE injection can last for 6-12 months* and it is safer for repeat dose when needed.

Hyruan ONE is a single injection treatment, usually called viscosupplementation injected directly into the knee by a certified doctor, usually a specialist, an orthopaedic surgeon, a rheumatologist and a general practitioner.

Hyruan ONE treatment does not involve any additional surgery or drugs (other than local anaesthesia, a topical spray or an injection under the skin to numb the knee area may be considered by your doctor).

You may start to feel the pain reduction 2-3 weeks after the treatment and the greatest pain reduction can be felt after week 10 to week 14*.

However, pain relief duration may vary across patient to patient depending on the severity of knee OA stages.

Reports shows for mild to moderate stage, patient may experience pain relief up to 6 months while some other patients may experience continuous pain relief beyond 6 months.

*Ha et al. BMC Musculoskeletal Disorders (2017) 18:223

Yes, you can receive Hyruan ONE treatment more than once. Hyruan ONE can be repeated safely.

It can be done as frequent as 3 months, depending on how long the pain relief last for each individuals.

One of the more recent study* shows patients who received 5 or more courses of hyaluronic acid treatment delayed their knee replacement operation by an average of 3.6 years. However, patients without hyaluronic acid treatment had their knee replacement surgery after an average of 9 months.

*Altman et al, The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review BMC Musculoskelet Disord, 2015 Oct 26;16:321